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Breakthrough in fight against diabetes

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A gene that controls the way the body responds to the hormone insulin has been identified, marking a breakthrough in the fight against diabetes.

Scientists believe a variation in the gene's DNA promotes insulin resistance, the primary cause of type 2 diabetes, which affects two million people in the UK.

The discovery could lead to new drug treatments that target the genetic fault and prevent the body failing to respond to insulin.

The hormone controls the way cells absorb glucose from the blood and use it to generate energy.

In type 2 diabetes, insulin often continues to be produced by the pancreas but it cannot be used properly.

The new genetic link, the first known to involve insulin resistance, was found after scientists screened the DNA of more than 14,000 people.

Diabetic foot ulcer treatment using prophylactic heart disease drugs cuts deaths

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Giving prophylactic heart disease drugs to patients with diabetic foot ulcers can significantly reduce mortality, a Scottish study has found.

According to a team from the Royal Infirmary of Edinburgh, a simple system of heart monitoring combined with preventative medicine could save the lives of thousands of patients with diabetic foot ulcers.

Topical phenytoin may improve foot ulcers healing for patients with diabetes

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Study suggests diabetes patients with recalcitrant neuropathic foot ulcers may benefit from treatment with topical phenytoin

Using topical phenytoin to treat recalcitrant neuropathic diabetic foot ulcers may improve wound healing according to a small scale study published in the Journal of Wound Care.

Vitamin C can Halt Diabetes Damage

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A team of US and British scientists has discovered that a combined therapy of insulin and vitamin C can stop disease-related blood vessel damage in patients with Type I diabetes.

Researchers at the Harold Hamm Diabetes Center in Oklahoma and the University Hospital of Coventry and Warwickshire, UK, recruited forty participants into a trial that involved providing vitamin C or insulin therapy, or both, for a range of time periods and assessing the effect of each therapy on endothelial injury, blood flow and oxidative stress. The patient group included a range of sufferers, from those recently diagnosed with the condition to those who had been controlling the illness for five years or more.

Prediction of Diabetic Foot Ulcer Occurrence Using Commonly Available Clinical Information

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OBJECTIVE—The ability of readily available clinical information to predict the occurrence of diabetic foot ulcer has not been extensively studied. We conducted a prospective study of the individual and combined effects of commonly available clinical information in the prediction of diabetic foot ulcer occurrence.

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